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Transcriptomic analysis of gefitinib-resistant EGFR-mutant NSCLC cells

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE123066
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We have employed a transcriptomic approach to find a molecular target that could compensate for the loss of EGFR signaling in NSCLC cell lines with acquired resistance to gefitinib with an EMT phenotype. Total RNA obtained from EGFR-mutant HCC4006 lung adenocarcinoma cells treated with increasing concentrations of gefitinib for 6 months (gefitinib resistant, GER), alone or in combination with the TGFB receptor inhibitor SB431542.
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2020-01-01
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