Gut microbiota and bile acid metabolism in infantile cholestasis

We aimed to access the gut bacterial changes associated with alterations in the bile acid (BA) metabolism in infantile cholestatic jaundice (CJ). We performed 16S rRNA gene analysis of fecal microbiota profiles from 126 infants including 45 healthy subjects (HC), 25 with impaired hepatic function (IHF), and 56 CJ cases, to determine the gut microbiome changes, and access their associations with fecal levels of 43 primary and secondary BAs and their conjugated forms and seven serological indexes of hepatic function.