Transcriptome analysis of subcutaneous adipose tissue from psoriatic lesion skin and peripheral non-lesional skin

Psoriasis, a prevalent chronic inflammatory skin disease, affects over 100 million individuals globally and is increasingly acknowledged as a systemic condition impacting the heart, blood vessels, and joints. A substantial body of research highlights a strong correlation between the severity of psoriasis and an elevated risk of cardiovascular diseases. Notably, treatments that alleviate dermatological symptoms have also been shown to reduce the formation of coronary plaques. Adipose tissue, functioning as a significant endocrine organ, secretes pro-inflammatory mediators that perpetuate the chronic low-grade inflammation typical of obesity. To investigate the molecular changes in adipose tissue associated with psoriasis, we collected subcutaneous adipose tissue samples from both psoriatic lesion skin (LS, n=8) and peripheral non-lesional skin (NLS, n=8), and conducted comprehensive transcriptomic analyses. The total RNA was isolated from subcutaneous adipose tissue samples from 8 psoriatic lesion skin and 8 peripheral non-lesional skin. The whole transcriptome analysis was perfrom by microarray