Dataset related to article "CRISPR Genome-Wide screening reveals chemosensor receptors as lipid-detecting regulators of macrophage functions in cancer"

This record contains raw data related to article "CRISPR Genome-Wide screening reveals chemosensor receptors as lipid-detecting regulators of macrophage functions in cancer"

Abstract:

The infiltration of macrophages is considered a hallmark of cancer progression and re-education of tumor-associated macrophages towards an anti-tumour status is considered a promising strategy of cancer immunotherapy. However, the mechanisms governing macrophage education by cancer cells remain largely elusive, posing challenges for therapeutic exploitation. To gain deeper insights into TAMs' plasticity, we conducted an unbiased genome-wide CRISPR screening on primary macrophages. Our investigation confirmed the role of known regulators, including Stat6, in orchestrating TAMs' responses and unveiled novel insights into TAMs' behaviour. We identified olfactory and vomeronasal receptors, commonly referred to as chemosensors, as major drivers of macrophages tumor-supportive status in multiple cancers. Collectively, our findings implicate chemosensors in macrophage sensing of the lipid-enriched milieu and highlight these receptors as therapeutic targets for enhancing antitumor immunity.