Radiotherapy Remodeling of the Breast Tumor Microenvironment Identified by Single Cell Omic Analysis

Radiotherapy is a widely used and highly effective treatment for many cancers, yet much of the biology underpinning its success or failure is rarely studied with the context of a functioning, in vivo tumor microenvironment. the polarity of the radiation-induced pro- and anti- tumor microenvironment response is likely influenced by innate tumor characters, as well as dose and duration of therapy. Because of these complexities, it has become increasingly important to study radiation response in patients while using clinically feasibly dose regimens and timeframes. Here we use single cell sequencing to examine the tumor and microenvironment response to radiotherapy in 20 HR positive breast tumors.