Patch-clamp recordings from layer 4 pyramidal cells in guinea pig V1 acute slices showing synaptic plasticity induced by paired extracellular stimulation and spiking under both normal conditions and pharmacological GABAA blockage.

This dataset contains patch-clamp recordings from individual pyramidal cells in layer 4
of acute slices from visual cortex area V1 in young (1-2 week old) guinea pigs. The main
purpose of the experiments was to examine synaptic plasticity responses of responses evoked
by electrical stimulation under normal conditions and under GABAA blockage (using bath application
of bicuculline). There are three sets of data: a voltage clamp control dataset (VC, n=17), a
current clamp control dataset (ICS, n=21) and a bicuculline voltage clamp dataset (VCB, n=38).

Complete recordings contain a baseline of at least 10 minutes, followed by a pairing protocol in which
extracellular stimulation was paired with an intracellularly-evoked (in current clamp) burst of spikes
and a post-pairing epoch of at least 10 minutes. Some datasets are incomplete or were excluded from
publication due to quality control (see below). This is indicated in the accompanying documentation.