AI-guided Cas9 engineering provides an effective strategy to enhance base editing. Homo sapiens

NIAID Data Ecosystem2026-05-02 收录

基因编辑优化

AI辅助蛋白质设计

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1192552 数据链接链接失效反馈

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AI-guided Cas9 engineering provides an effective strategy to enhance base editing Raw sequence reads

创建时间：

2024-11-30

Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair Pathways

基因编辑优化

干细胞基因工程

Improving cytosine base editor (CBE) and prime editor (PE) in human pluripotent stem cells (hPSCs) via dual inhibition of DNA damage response and DNA repair pathways

Figshare2024-05-12 更新80

"A streamlined base editor engineering strategy to reduce bystander editing

基因编辑优化

基因治疗

Base editing (BE) can permanently correct over half of known human pathogenic genetic variants without requiring a repair template, thus serving as a promising therapeutic tool to treat a broad spectr

NIAID Data Ecosystem40

Replacing the SpCas9 HNH domain by deaminases generates compact base editors with an alternative targeting scope [DNA-seq]

碱基编辑器

基因编辑优化

Base editors are RNA-guided deaminases that enable site-specific nucleotide transitions. The targeting scope of these Cas-deaminase fusion proteins critically depends on the availability of a protospa

NIAID Data Ecosystem40

Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [Amplicon]. Functional screening in human HSPCs identifies optimized protein-based enhancers of Homology Directed Repair [Amplicon]

基因编辑优化

细胞基因治疗

Homology Directed Repair (HDR) enables precise genome editing and holds great promise in the gene therapy field. However, the implementation of HDR-based therapies is hindered by limited efficiency in

NIAID Data Ecosystem40

Mutation-specific reporter for optimization and enrichment of prime editing

基因编辑优化

生物机制研究

Prime editing is a versatile genome-editing technique that shows great promise for the generation and repair of patient mutations. However, some genomic sites are difficult to edit and optimal design

NIAID Data Ecosystem40

AI-guided Cas9 engineering provides an effective strategy to enhance base editing. Homo sapiens

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