Biochemical reactions rules, parameter values and uncertainty.

Reversible reactions are parameterized by an equilibrium constant and an off-rate; the on-rate is calculated as . Irreversible reactions have a single reaction rate constant. The uncertainty in the parameter values is indicated by a fold change. The evidence for parameter values is grouped into:(***)values stated in the given reference,(**)values inferred from data in the given reference and(*)plausible values inferred from biochemical background knowledge.