Effect of subchronic oral administration of glucosamine in the regulation of body weight, glycemia and dyslipidemia induced hypercholesterolemic Wistar rat

Objective: This study evaluated the effect of oral glucosamine on overweight and dyslipidemia caused by a high-fat diet in rats.Methods: Four groups of Wistar rats: fed with commercial rodent food and drinking water without (control group) and with glucosamine (500 mg kg-1 per day) and a high-fat diet enriched with 24% (g/g) butter pork and drinking water without and with glucosamine, for 22 weeks; the body weight, abdominal fat, blood glucose, triglycerides, total cholesterol, and high density lipoprotein in serum were evaluated.Results: Body weight gain, increased blood glucose levels and dyslipidemia were observed in the high-fat diet group versus the control group (p0.05), regulated body weight, and high density lipoprotein and glycaemia (p