Data from: Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium

Here, we applied in vivo bioluminescent imaging to mice systemically
injected with AAV vectors containing different combinations of capsids,
enhancers, and timing of delivery. Longitudinal tracking of expression
directed by different TREEs revealed distinct amplitudes and durations of
reporter gene expression in the injured heart. The liver-de-targeted AAV
capsid, AAV.cc84, could deliver TREEs either pre- or post-cardiac injury
to negate off-target expression in the liver while maintaining
transduction in the heart. By screening AAV9-based capsid libraries dosed
systemically in mice post-cardiac injury, we discovered a new capsid
variant, AAV.IR41, with enhanced transduction in cardiac injuries and with
elevated transduction of TREE driven transgenes versus conventional AAV9
vectors. Datasets include images, image analyses, sequencing results,
spreadsheets, and statistical analyses.