The large intracellular C-terminus of the pro-inflammatory P2X7 ion channel receptor (P2X7R) is associated with diverse P2X7R-specific functions. Cryo-EM structures of the closed and ATP-bound open fu
Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels are tetramers that generate electrical rhythmicity in special brain neurons and cardiomyocytes. The channels are activated by mem
Thermal activation thresholds estimated by an Arrhenius plot using data obtained from Xenopus laevis oocytes expressing TRPV1 from extant and ancestral clawed frog species. The data for currents and t