Methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives

ChEBI2013-03-15 更新2026-07-21 收录

母细胞瘤表观遗传学

干细胞重编程

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-1275 数据链接链接失效反馈

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Methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives

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2013-03-15

DNA methylome evolution and reprogramming in recurrent glioblastoma

母细胞瘤表观遗传学

DNA甲基化

Recurrent glioblastoma (GBM) has a grim prognosis, though MGMT promoter methylation and IDH mutation provide a significant survival advantage. The product of IDH mutation, 2-hydroxyglutarate, increas

NIAID Data Ecosystem60

Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]. Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency [RNA-seq]

干细胞重编程

染色质可及性调控

Chemical induction of pluripotency (CIP) is an ideal way to reprogram cell fate, but remains poorly understood. Here we report the development of an efficient CIP protocol and the chromatin accessibil

NIAID Data Ecosystem40

Differential gene expression of neuroblastoma cells stably expressing doxycycline-inducible DOT1L small hairpin RNA. Homo sapiens

母细胞瘤表观遗传学

DOT1L敲低效应

We were interested in studying the role of DOT1L-mediated H3K79 methylation on N-Myc target gene transcription in MYCN-induced neuroblastoma. We aimed to determine whether knocking down DOT1L in MYCN-

NIAID Data Ecosystem30

Transcription factor NKX3-1 is required for reprogramming to pluripotency and can replace OCT4 in mouse and human iPSC induction [ATAC-seq]. Homo sapiens

干细胞重编程

转录因子功能

Resolution of early molecular events preceding endogenous OCT4 activation is critical to understanding the mechanism of reprogramming somatic cells to induced pluripotent stem cells (iPSCs), yet captu

NIAID Data Ecosystem40

α-Ketoglutarate inhibits the pluripotent-to-totipotent state transition

干细胞重编程

代谢调控机制

In early mouse embryogenesis, the distinct enrichment of α-ketoglutarate (αKG) in blastocysts and L-2-hydroxyglutarate (L-2HG) in 2-cell (2C) embryos serves as a key metabolic signature. While elevate

NIAID Data Ecosystem30

Methylation profiling of glioblastoma neural stem cells and reprogrammed derivatives

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