Results of the replication association analyses of the top 100 SNPs in the Norway, ICGN, and NETT/NAS populations.

aLogistic regression analyses using age, gender, pack years of smoking and current smoking status as co-variates.bInternational COPD Genetics Network (ICGN) population. PBAT version 3.6 analyses using age, gender, pack-years of smoking, current smoking status and center as co-variates.cNational Emphysema Treatment Trail/Normative aging study (NETT/NAS). Logistic regression using age and pack years of smoking (all the subjects are males and ex-smokers, so adjustments for gender and current smoking status were not included).dFisher's combined probability test was applied to combine the P-values from Bergen Cohort, ICGN cohort and NETT/NAS study.P values in bold are above the genome-wide significance level (p?7).Numbers in Bold are genome-wide significant (p value?7).eRisk alleles were different in the ICGN or NETT/NAS population compared to the Bergen discovery cohort.