Transcription profiling of mouse liver cells with liver specific deletion of Irs1 and/or Irs2 and Foxo1during fasting and feeding

The effect of liver specific deletion of the insulin receptor substrate-1 (Irs1) and/or Irs2 upon gene expression in the fasted and fed liver of mice; and the effect of liver specific Foxo1 deletion in the Irs1 and Irs2 knockout liver during fasting and feeding.本数据集涵盖两项研究内容：其一为小鼠在禁食与进食两种生理状态下，肝脏特异性敲除胰岛素受体底物1（insulin receptor substrate-1, Irs1）和/或Irs2对肝脏基因表达的调控影响；其二为在Irs1与Irs2双基因敲除的肝脏组织中，肝脏特异性敲除叉头框O1（Foxo1）在禁食与进食状态下的作用效应。