Differentially expressed genes in the synovial tissue from FVIII-KO mice after hemarthrosis and FVIII treatment. Synovial tissue was harvested at baseline, day 3 and day 14 post-injury. RNA was purified and analyzed by RNA sequencing using an Illumina NextSeq500 platform (75 bp; single‐end). The R BioConductor packages tximport, edgeR, and limma were used to read estimate counts from RSEM, trimmed mean of M-values (TMM) normalization was applied, and the limma-voom method was used for differential expression analyses (criteria: adjusted p-value <0.05). The baseline group was compared to saline treatment groups, and saline-treated groups were compared to rhFVIII and mFcFVIII treatment groups on day 3 and day 14. This table lists the total number of DEGs and the number of up or down-regulated DEGs in each group.

Differentially expressed genes in the synovial tissue from FVIII-KO mice after hemarthrosis and FVIII treatment. Synovial tissue was harvested at baseline, day 3 and day 14 post-injury. RNA was purified and analyzed by RNA sequencing using an Illumina NextSeq500 platform (75 bp; single‐end). The R BioConductor packages tximport, edgeR, and limma were used to read estimate counts from RSEM, trimmed mean of M-values (TMM) normalization was applied, and the limma-voom method was used for differential expression analyses (criteria: adjusted p-value <0.05). The baseline group was compared to saline treatment groups, and saline-treated groups were compared to rhFVIII and mFcFVIII treatment groups on day 3 and day 14. This table lists the total number of DEGs and the number of up or down-regulated DEGs in each group.