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Whole genome transcriptional profile of PyMT/SIRT6 vs PyMT mammary tumors. Mus musculus

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NIAID Data Ecosystem2026-03-10 收录
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We compared the transcriptional profile of mammary tumors spontaneously developed in PyMT transgenic mice either bearing or not additional copies of the endogeneous SIRT6 gene. Overall design: We crossed genetically-engineered mice overexpressing functionally competent SIRT6 protein (Sirt6BAC mice) (Anderson et al., 2015) to PyMT mice. PyMT-transgenic females either bearing Sirt6BAC allele or wild-type were sacrified at 12 weeks of age. Mammary tumors spontaneously developd in these mice were excised and subject to micorarray analysis.

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2017-01-19
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