Metal-Free, Photoinduced On-DNA Synthesis of β‑Hydroxy Sulfides

We present a metal-free photochemical
strategy for the synthesis
of on-DNA β-hydroxy sulfides, which are essential pharmacophores
with limited access via existing DNA-encoded library (DEL) methodologies.
This innovative hydrothiolation features a broad substrate scope with
both thiols and olefins. Its operational simplicity and excellent
DNA compatibility enable the efficient construction of diverse DELs,
significantly expanding the accessible chemical space for drug discovery
and providing a new tool for identifying novel therapeutics.