Supplementary Data for: Leveraging Genome-wide Association Studies to Identify Pathogenic Variants for Breast Cancer among Multiple Continents

This dataset contains supplementary tables supporting the manuscript "Leveraging Genome-wide Association Studies to Identify Pathogenic Variants for Breast Cancer among Multiple Continents". The dataset includes three comprehensive tables: Supplementary Table S1: Complete list of 2,454 initial GWAS associations with breast cancer extracted from the GWAS Catalog database. Supplementary Table S2: Filtered dataset of 1,219 associations after applying genome-wide significance threshold (p-value < 10⁻⁸). Supplementary Table S3: Final 14 missense variants with complete functional annotations including missense mutation status, cis-eQTL mapping, CADD scores, SIFT predictions, PolyPhen-2 predictions, and AlphaMissense scores, along with per-criterion pass/fail status for each annotation tool. The data supports the identification and prioritization of breast cancer-associated genetic variants across multiple continental populations, providing insights for precision medicine applications and drug repositioning opportunities.