Supplementary Material for: Fetal High-Risk APOL1 Genotype Increases Risk for Small for Gestational Age in Term Infants Affected by Preeclampsia.

Background: Hypertensive disorders of pregnancy cause fetal growth restriction and increased maternal morbidity and mortality, especially in women of African ancestry. Recently, preeclampsia (PE) risk was linked with African polymorphisms in the Apolipoprotein L1 (APOL1) gene. Objectives: We assessed the effect of APOL1 genotype on fetal growth outcomes of pregnancies with and without PE. Method: We conducted an unmatched case-control study of 1,358 mother-infant pairs from two independent cohorts of Black women. Results: Term PE cases with high-risk APOL1 genotypes were more likely to be small for gestational age compared to APOL1 low-risk term cases or APOL1 high-risk controls (odds ratios of 2.8 and 5.5, respectively). Among preterm cases, APOL1 genotype was associated with PE, significant for both recessive and additive inheritance patterns. Conclusions: Fetal APOL1 genotype was associated with PE in preterm infants but altered fetal growth in term infants indicating APOL1 genotype impacts conditions associated with placental insufficiency.