Expression data from Rat heterotopic cardiac transplants

Heterotopic cardiac transplants were constructed in male Wistar Furth (allograft donor) and ACI (host) rats. Rats were divided into three groups consisting of no treatment, treatment with a sub-therapeutic dose of cyclosporin A, and treated with combination of a sub-therapeutic dose of cyclosporin A and allochimeric peptide. The allografts were harvested at defined periods post-transplantation and RNA was harvested to monitor gene expression changes resulting from the various treatments in T-cells and in heart cells.本研究以雄性Wistar Furth大鼠作为同种异体移植供体，ACI大鼠作为受体宿主，构建异位心脏移植模型。将大鼠分为三组，分别为未处理组、亚治疗剂量环孢素A (cyclosporin A) 单药治疗组，以及亚治疗剂量环孢素A联合异嵌肽 (allochimeric peptide) 治疗组。于移植后既定时间点收集同种异体移植物，并提取RNA，以监测不同处理方式下T细胞与心肌细胞内的基因表达变化。