Aberrant striatal but not nigral gene expression profiles are specifically associated with dyskinesia behavior following levodopa treatment in the 6-hydroxydopamine lesioned rat

Levodopa-induced dyskinesia (LID) is a common consequence of prolonged pharmacotherapy for Parkinson's disease (PD). While LID becomes more common with long term exposure to levodopa, its development can be quite variable. We leveraged the variable expression of LID in a rat model to interrogate differential gene expression in the substantia nigra and striatum of animals that develop LID and those that do not. Differential expression of genes associated with LID was found only in striatum, not substantia nigra.左旋多巴诱发的异动症（Levodopa-induced dyskinesia, LID）是帕金森病（Parkinson's disease, PD）长期药物治疗的常见并发症。尽管长期暴露于左旋多巴会增加LID的发生风险，但其发病进程存在显著异质性。本研究借助大鼠模型中LID表型的个体差异，对出现LID与未出现LID的动物的黑质（substantia nigra）和纹状体（striatum）开展差异基因表达分析。研究发现，仅在纹状体中检测到与LID相关的差异表达基因，黑质中未观察到此类基因表达变化。