Significant CpG sites in a linear regression model.

Methylation treated as a continuous outcome (M-values: PBC and COMBAT on chip) and menarcheal age category (>11 vs. ≤11 years) treated as a categorical exposure. Adjusting for age at blood collection, case-control status, and position on the chip. Analysis of all subjects or of only the 240 subjects that remained healthy for at least 5 years following recruitment yielded the same results. ∝P value from a liner regression model where methylation is treated as a continuous outcome (M-values: PBC and COMBAT on chip) and the effect of age at menarche as a categorical variable (>11 vs. ≤11 years), adjusted for age, case-control status, and chip position. ≠Q value: False Discovery Rate (FDR) corrected P-value. ≈The regression coefficient for each probe; change in methylation for having an age at menarche >11 years vs. ≤11 years.