Available IPD datapackage for study 'A Multiple-Dose, Open-Label, Phase 1, Pharmacokinetic, Pharmacodynamic, and Safety Study of Avonex® in Chinese Healthy Volunteer Subjects'

Rationale for the Study:

The purpose of this study is to characterize the pharmacokinetic (PK) and pharmacodynamic
(PD) profile of Avonex in Chinese healthy volunteer subjects. Data from this study will be
used to support registration of Avonex in China.

Study Design:

This is a multiple-dose, single-arm, open-label, PK/PD and safety study. Four weekly
injections of Avonex will be administered intramuscularly (IM). Frequent (intensive) blood
samples will be collected with the first and fourth injections of Avonex, and a sparse blood
sample will be collected with the second and third injections of Avonex.