Longitudinal Gut Metagenomics profiling of ME/CFS

Here, we performed deep longitudinal multi-omics clinical phenotyping of ME/CFS, which included shotgun metagenomics of gut microbiota. Overall, ME/CFS was characterized by reduced gut microbiome diversity and richness, with high heterogeneity, and depletion of microbial BCAA and short-chain fatty acid biosynthesis capacity, alongside increased tryptophan and benzoate metabolism. These microbiome changes drive host-microbiome interactions differently, particularly with mucosal and inflammational immune responses, and plasma lipids. For more details, please check our publication at [TBD].