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Chromatin Remodelers in Cardiometabolic Heart Failure with Preserved Ejection Fraction

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE289265
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Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is highly prevalent and associated with a poor outcome. Pathological gene expressions in heart failure are accompanied by changes in active histone marks without major alterations in DNA methylation. Whether chromatin modifications participate to obesity-induced HFpEF is largely unknown. We will investigate whether chromatin marks participate to obesity-induced HFpEF in vivo. RNA-seq in cardiomyocytes obtained from Control and HFpEF with and without SET7 knockout hearts were analyzed
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2025-06-06
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