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Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study

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Zenodo2025-11-25 更新2026-05-26 收录
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The following data was used in analysis for the paper " "Interrogating DNA methylation associated with Lewy body pathology in a cross brain-region and multi-cohort study" J. Harvey, J. Imm et al. (2025) For analysis code used please refer to "https://github.com/UoE-Dementia-Genomics/LB-Meta-Analysis" Data is organised into compressed directories as follows. UKBBN: Processed DNA methylation matrices (PFC = Prefrontal Cortex, CNG = Anterior Cingulate Cortex), pheno files and Epigenome wide association study summary statistic outputs for the UK- Brain Bank Network cohort. NBB: Pheno files and Epigenome wide association study summary statistic outputs for the Netherlands Brain Bank cohort. Processed DNA methylation data available at GEO GSE203332 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE203332 BDR: Processed DNA methylation matrices (PFC = Prefrontal Cortex), pheno files and Epigenome wide association study summary statistic outputs for the Brains for dementia research cohort. Meta: Meta analysis summary statistics used in analysis Genotyping: Genotyping data, phenotyping and quantitative trait loci summary statistics for samples from the UKBBN Cohort Reference testing files: Additional reference files utilised in genomic enrichment and colocalisation testing analysis

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2025-11-25
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