Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors
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Design and Synthesis of Thiophene Dihydroisoquinolins as Novel BACE-1 Inhibitors Descriptor: 3-(4-bromothiophen-3-yl)-N-(6-chloro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-alanine, Beta-secretase 1, ZINC ION Authors: Yao, N, Brecht, E. Deposit date: 2012-11-16 Release date: 2013-03-06 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. Bioorg.Med.Chem.Lett., 23, 2013
创建时间：
2012-11-16
