Transcriptomic Signaling Pathways involved in a naturalistic model of Inflammation-related Major Depressive Disorder and its remission

This study aimed at identifying molecular biomarkers specific to inflammation-related subtype of MDD in order to improve diagnosis and treatment. For this, we performed whole-genome expression profiling from peripheral blood in a naturalistic model of inflammation-associated MDD represented by comorbid depression in obese patients. Depressed patients were diagnosed with the Mini-International Neuropsychiatric Interview and the 10-item, clinician administered, Montgomery-Asberg Depression Rating Scale. From a cohort of 100 massively obese patients we selected 33 of them for transcriptomic analysis with 24 patients that were again analyzed 4-12 months after bariatric surgery.