Enantioselective Diels–Alder Reaction of 1,2-Dihydropyridines with Aldehydes Using β‑Amino Alcohol Organocatalyst
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https://figshare.com/articles/dataset/Enantioselective_Diels_Alder_Reaction_of_1_2_Dihydropyridines_with_Aldehydes_Using_Amino_Alcohol_Organocatalyst/2243863
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资源简介：
The
enantioselective Diels–Alder reaction of 1,2-dihydropyridines
with aldehydes using an easily prepared optically active β-amino
alcohol catalyst was found to provide optically active isoquinuclidines,
an efficient synthetic intermediate of pharmaceutically important
compounds such as oseltamivir phosphate, with a satisfactory chemical
yield and enantioselectivity (up to 96%, up to 98% ee). In addition,
the obtained highly optically pure isoquinuclidine was easily converted
to an optically active piperidine having four successive carbon centers.
创建时间：
2014-10-17
