Schizosaccharomyces pombe strain:TA1 Epigenomics

The conserved serine/threonine protein kinase TOR (Target of Rapamycin) is a major regulator of eukaryotic cellular and organismal growth and a valuable target for drug therapy. TOR is found at the core of two evolutionary conserved complexes, TOR complexes 1 and 2 (TORC1 and TORC2). In Schizosaccharomyces pombe, TORC2 responds to glucose levels and is required through the activation of the protein kinase Gad8 (AKT in human cells) for well-regulated cell cycle progression, starvation responses and cell survival. Here we report that loss of TORC2-Gad8 results in loss of gene silencing at the heterochromatic mating-type and subtelomeric regions.