Figure S1. Generation of the PHGDHtetO allele. Figure S2. Tissues from mice with long-term exposure to doxycycline diet show variable PHGDH expression. Figure S3. PHGDH expression leads to melanin acc
Many tissues of the human body encounter hyperosmotic stress. The effect of extracellular osmotic changes on melanin production has not yet been elucidated. In this study, we determined that hyperosmo
The TYRP1 gene can affect melanogenesis in melanocytes of the Xiang pigs, and ssc-miR-221-3p targets the TYRP1 gene to affect melanogenesis in melanocytes of the Xiang pigs. To investigate the mRNAs a
Western blotting and quantitative RT-PCR was used to identify siRNAs that impact tyrosinase, MITF, and Melan-A protein levels or impact tyrosinase and MITF mRNA levels in MNT-1 cells (Figure 2 A, B).