Genotyping of CD28 gene SNPs in breast cancer patients and controls.

1For SNP rs3119686, no GG genotype was detected in this study and the frequency of G allele is only 1.75%. Thus, only allelic P value was calculated between cases and controls in Table 3.
2Minor allele ‘a’ and the major ‘A’ are shown in the table. ‘AA’, ‘Aa’, ‘aa’ represent a given variant for each SNP genotyped.
3the number of cases in study cohort was 565.
4the number of controls in study cohort was 605.
5The P values were accessed using Plink and SPSS software under an additive model (AA vs. Aa vs. aa), dominant model (aa+Aa vs. AA), and recessive model (aa vs. Aa+AA) respectively. Significant values (P<0.05) are in bold.
6Estimated odds ratio (OR) and 95% confidence interval (CI) above were assessed under an dominant model (aa+Aa vs. AA) using logistic regression with Plink 1.07.