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MYC-deficiency impairs the development of effector/memory T lymphocytes

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NIAID Data Ecosystem2026-03-12 收录
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Using scRNA-seq we investigate the impact of the absence of MYC on physio-pathological development of PTEN-proficient or PTEN-deficient T lymphocytes. We demonstrate that MYC-deficient effector/memory T cells is drastically reduced. MYC is then essential for effector/memory differentiation Single cell RNA-seq study of T lymphocyte differentiation in Pten and/or Myc deleted mice

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2021-09-13
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