RAS-p110α signalling pathway in macrophages and its impact on both the initiation and resolution of inflammation

This study presents a secretome analysis of bone marrow-derived macrophages (BMDMs) from wild-type (WT) and RAS-p110α-disrupted macrophages. Samples were collected under both unstimulated conditions and during phagocytosis of apoptotic cells. The aim was to identify differential regulatory factors secreted by macrophages across these four conditions, highlighting the impact of disrupted RAS-p110α signaling on macrophage function and secretome composition.