Obesity-disrupted H3K4me3 in hematopoietic stem progentior cells in mice

Obesity alters long-term functions of hematopoietic stem cells (HSPCs), which are associated with myelopoitic bias and maladapted pro-inflammatory phenotype. H3K4me3 histone modification is generally considered an activating histone marks and is also liked with epigenetic programming for trained immunity. We aim to identify how obesity in mice alter H3K4me3 marks in HSPCs and study its impact on HSPC functions in vitro and in vivo. Overall design: Comparative H3K4me3 marked peak analysis of ChIP-seq data for hematopoietic stem progenitor cells (Lin-Sca1+cKit+) obtained from the bone marrow of C57B6/J mice fed a high-fat diet or a normal-fat diet.