Administration of EGCG and synthetic derivate compound 30 produce an increase in CCI-mediated thermal paw withdrawal latency in a dose- and time-dependent manner.

The latency to paw withdrawal to a thermal stimulus was recorded in CCI-mice treated with vehicle or different doses (10, 30, 50 and 100 mg/kg; i.p.) of EGCG, compound 23 and compound 30 at 7 and 21 days post injury (dpi). The results are expressed in seconds and data shown are the mean ± SEM (n = 5). Data were analyzed by two-way ANOVA with Bonferroni’s post-hoc test.*** pAdministration of EGCG and synthetic derivate compound 30 produce an increase in CCI-mediated thermal paw withdrawal latency in a dose- and time-dependent manner.