Zebrafish macroH2A variants analysis reveals distinct embryo localization and function-ChipSeq Information. Danio rerio

Most mouse and cell-based studies have shown that macroH2A histone variantspredominantly associate with heterochromatin and have been associated withgene repression, and with an important function in cell differentiation andinhibiting acquisition of pluripotency of pluripotency. However fewer studies haveanalysed the role of macroH2A during early embryo development.In this project transgenic zebrafish lines were developed expressing macroH2Aisoforms (mH2A1 and mH2A2) fusion proteins (GFP) under endogenousidentified promoters, to study their function during embryogenesis.