Comparisons of demographic data and clinical parameters among the three groups.

Notes: To save the space, data with less clinical relevance, without statistical significance, and at ICU admission were presented in the online supporting tables only.EG, ≦ 1 day; IG, 2–3 days; LG, ≧ 4 days between ICU admission and RRT initiation. Values are presented as mean ± standard deviation or number (percentage) unless otherwise stated. P-value was calculated using Kruskal-Wallis Rank Sum Test, Wilcoxon Rank Sum Tests in two sample comparison with Bonferroni correction and Fisher’s Exact Test for count data.¥the percentage was calculated dividing by number of the deaths;∣ EG versus IG;∥ LG versus IG;*P**Paazotemia was defined as BUN>80 mg/dl and creatinine>2 mg/dl;bfluid overload means CVP>12 mmHg;coliguria was defined as urine output dhyperkalemia denotes serum potassium>5.5 mmol/l, acidosis denotes pHAbbreviations: APACHE II, Acute Physiology and Chronic Health Evaluation II; BMI, body mass index; BUN, blood urea nitrogen; CKD, chronic kidney disease; CVP, central venous pressure; CVVH, continuous venous-venous hemofiltration; DM, diabetes mellitus; ECMO, extracorporeal membrane oxygenation; EG, early group; eGFR, estimated glomerular filtration rate; GCS, Glasgow Coma Scale; ICU, intensive care unit; IE, inotropic equivalent; IG, intermediate group; LG, late group; MAP, mean arterial pressure; RRT, renal replacement therapy; SOFA, Sequential Organ Failure Assessment; WBC, white blood cell.