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Developmental chromatin programs determine oncogenic competence in melanoma [RNA-seq]

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP314729
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Transcriptional profile of human ES-cell (hPSC) derived melanoma cell models Overall design: Human ES cells were differentiated into neural crest (NC), melanoblast (MB) or melanocytes (MC). These were either WT or triple knockout (3xKO) for p53, p16, RB1. A dox-inducible cassette was integrated into the cells to activate the BRAFV600E oncogene upon addition of doxycyline.
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2021-04-16
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