Longitudinal analysis of the microbiome and metabolome in the 5xfAD mouse model of Alzheimer's disease

Here we evaluate longitudinal microbiomes and metabolomes from a popular transgenic mouse model for familial Alzheimer’s disease (5xfAD). This data is comprised of metagenomics of both cecal and fecal samples, metabolomics of fecal samples, and metabolomics of blood plasma. Samples were collected from 5xfAD mice and their WT B6J littermates from 4 – 18 months of age. Differences in microbiome and metabolite composition with relation to genotype, sex, age, and housing were explored. This study was conducted as part of the MODEL-AD consortium (model-ad.org).

Methods
This dataset consists of four text files, each of which has undergone extensive pre-processing in R. The relevant metadata and data are combined in each file. The files include: 

PlasmaMX_data.txt: plasma metabolomics data
FecalMX_data.txt: fecal metabolomics data
Taxonomy_data.txt: fecal and cecal microbiome data
Turicibacter_data.txt: Bowtie2 data for three species of Turicibacter in fecal and cecal samples

Please see the manuscipt methods for more information (https://doi.org/10.1128/mbio.01794-22).