DYNAMICS OF AMINO ACID METABOLISM, GENE EXPRESSION, AND CIRCULOMICS IN A RECOMBINANT CHINESE HAMSTER OVARY CELL LINE ADAPTED TO MODERATE AND HIGH LEVELS OF EXTRACELLULAR LACTATE

This study characterizes the phenotype of a recombinant CHO K-1 cell line that was gradually adapted to moderate and high levels of extracellular lactate and examines the genomic content and role of extrachromosomal circular DNA (eccDNA) and gene expression on the adaptation process.