Data_Sheet_1_Stem Cell-Based Therapy for Experimental Ischemic Stroke: A Preclinical Systematic Review.docx

Stem cell transplantation offers promise in the treatment of ischemic stroke. Here we utilized systematic review, meta-analysis, and meta-regression to study the biological effect of stem cell treatments in animal models of ischemic stroke. A total of 98 eligible publications were included by searching PubMed, EMBASE, and Web of Science from inception to August 1, 2020. There are about 141 comparisons, involving 5,200 animals, that examined the effect of stem cell transplantation on neurological function and infarct volume as primary outcome measures in animal models for stroke. Stem cell-based therapy can improve both neurological function (effect size, −3.37; 95% confidence interval, −3.83 to −2.90) and infarct volume (effect size, −11.37; 95% confidence interval, −12.89 to −9.85) compared with controls. These results suggest that stem cell therapy could improve neurological function deficits and infarct volume, exerting potential neuroprotective effect for experimental ischemic stroke, but further clinical studies are still needed.

干细胞移植在缺血性卒中治疗中展现出巨大潜力。本研究通过系统评价、荟萃分析和荟萃回归分析，探讨了干细胞治疗在缺血性卒中动物模型中的生物学效应。从数据库的建立之初至2020年8月1日，我们检索了PubMed、EMBASE和Web of Science数据库，共纳入了98篇符合标准的出版物。这些研究涉及约141个比较，纳入了5200只动物，主要评估了干细胞移植对神经系统功能和梗死体积的影响，并将其作为卒中动物模型中的主要结局指标。与对照相比，基于干细胞的疗法可以显著改善神经系统功能（效应量，-3.37；95%置信区间，-3.83至-2.90）和梗死体积（效应量，-11.37；95%置信区间，-12.89至-9.85）。这些研究结果提示，干细胞疗法可能有助于改善神经系统功能缺陷和梗死体积，并可能对实验性缺血性卒中发挥潜在的神经保护作用，但尚需进一步的临床研究以证实其疗效。