eQTL GWAS association data for ACE2 and TMPRSS2 in lung tissue from Lung eQTL Consortium

Lung eQTL Consortium genetic association estimates were obtained in 1,038 individuals of European ancestry. Tissue samples were obtained at three different institutions: University of British Columbia, Laval University, and University of Groningen. Genome-wide eQTL analysis was performed for the expression for ACE2 using probe 100134205_TGI_at and two non-control probes for TMPRSS2, 100130004_TGI_at and 100157336_TGI_at. All participants were genotyped using the Illumina Human 1M Duo BearChip and the genotypes were imputed using the Haplotype Reference Consortium reference panel. Expression values were first standardized for age, sex, and smoking status using robust linear regression. Genetic associations were estimated in each cohort separately using a linear additive genetic model. The estimates were combined across cohorts using an inverse-variance weighted model with fixed-effects.