Experimentally validated signalogs and their orthologs.

We experimentally validated 6 novel Notch pathway components in C. elegans. 4 of them have been characterized by at least one loss-of-function mutant allele. None of these mutations caused altered morphology, behavior, or survival, i.e., these mutant animals appear superficially wild-type. Fly and human orthologs are also listed. Signalogs are classified into 5 groups (signalog classes) based on their known properties (see Methods and Fig. 3a). In the SignaLink database, each protein is annotated with one or more pathway role (e.g., co-factor, receptor).