Sodium butyrate ameliorates deoxynivalenol-induced oxidative stress and inflammation in the porcine liver via NR4A2-medicated histone acetylation

Mycotoxin-induced liver injury is often accompanied by oxidative stress (OS) and inflammation. However, the pathophysiological mechanism and the modulator involved remain elusive. This study aimed to investigate the potential mechanism of sodium butyrate (NaBu) in modulating hepatic anti-oxidation and anti-inflammation pathways in the deoxynivalenol (DON)-exposed piglets. Our results indicated that a natural antimycotic additive NaBu could mitigate hepatic OS and inflammatory responses possibly via NR4A2-mediated histone acetylation.