Disruption of RNAPII transcription elongation links Oncogenic splicing factor mutations to replciation stress and targetable alterations in chromatin landscape [CHD ChIP-Seq]

To investigate changes in the CHD1 distribution across different conditions, we peformed ChIP-seq using antibody against the CHD1 in K562 cells at 4 days after modified allele expression We then performed coverage plot analyses using data obtained from ChIP-seq from IP fractions to investigate CHD1 distribution changes ChIP-seq against CHD1 in K562 cells across different conditions at 4 days post doxycycline induction