Human Liver Cohort (HLC)
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https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000253.v1.p1
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The Human Liver Cohort (HLC) study aimed to characterize the genetic architecture of gene expression in human liver
using genotyping, gene expression profiling, and enzyme activity measurements of Cytochrom P450. The HLC was assembled
from a total of 780 liver samples screened. DNA samples were genotyped on the Affymetrix 500K SNP and Illumina 650Y
SNP genotyping arrays. Only data from those samples which were collected postmortem are accessible through this submission.
These 228 samples represent a subset of the 427 samples included in the Human Liver Cohort Publication (Schadt, Molony
et al. 2008, PMID: 18462017).
RNA samples were profiled on a custom Agilent 44,000 feature microarray composed of 39,280 oligonucleotide probes targeting
transcripts representing 34,266 known and predicted genes, including high-confidence, noncoding RNA sequences. Gene Expression
data for the samples from which it could be obtained is available in GEO under accession number GSE9588.
Results and networks will be made available for download from Sage Bionetworks.]]>
Mapping the Genetic Architecture of Gene Expression in Human Liver
创建时间：
2010-04-23
