Comparison of our rotenone ST models with other models.

Data on the rotenone ST and SYS administration models are from our study and other studies, while data on the MPTP models are all from reports by others. Animal, animal used for the research; Instrument, special instrument or routes of administration; Nutritional status, the nutritional status of PD animal models and whether supplementation is required; Peripheral toxicity, peripheral organ toxicity caused by the neurotoxin; Application, whether the model is suitable for the study of pathogenesis, pathophysiological research, or drug screening of PD; Slow progression, idiopathic PD-like slow progression; Selective degeneration, selective degeneration of DA neurons; Long-term progression, long-term (more than three months) progression without intervention; Extensive involvement, ability to reproduce extensive pathological involvement observed in PD patients; Cost, costs of neurotoxin drugs, instruments, nutritional supplementation (ST, Stereotaxical Infusion; SYS, Systemic administration; S.C., subcutaneous injection).