GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to the reduced risk of gastric cancer

Propose: The purpose of this study is to evaluate the contribution of GBAP1 genetic variants to the risk of gastric cancer (GC) occurrence among a Chinese Han population.

Methods: This study included 509 GC patients and 507 healthy controls. The genotypes of GBAP1 polymorphisms were detected by Agena MassARRAY platform. Logistic regression analysis was used for the association between GBAP1 polymorphisms and GC predisposition by calculating Odds ratio (OR) and 95% confidence interval (CI) adjusted for age and gender.

Results: GBAP1 rs140081212 (OR = 0.51, p = 4.50´10-07), rs1057941 (OR = 0.48, p = 1.19´10-08) and rs2990220 (OR = 0.46, p = 7.34´10-09) contribute to the reduced risk of GC incidence. Interestingly, the contribution of GBAP1 genetic variants to GC susceptibility was associated with age, gender, BMI and the status of smoking and drinking. Besides, rs140081212 (OR = 0.47, p = 1.70´10-06), rs1057941 (OR = 0.43, p = 4.43´10-08) and rs2990220 (OR = 0.43, p = 2.66´10-07) variants had the relationship to the decreasing risk of gastric adenocarcinoma.

Conclusion: Our research suggested that GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) might provide a protective effect on GC occurrence among a Chinese Han population. Our finding might increase the understanding of molecular genetics in gastric carcinogenesis.