Effects of the subcutaneous administration of 5 mg/kg of SNC-80 alone or combined with 2 mg/kg of naltrindole on the mechanical allodynia (von Frey filaments strength, g) in db/db mice.
Objective: Tapentadol is effective in the treatment of neuropathic and nociceptive pain and in acute and chronic pain conditions; two mechanisms combining opioid µ-receptor agonism and noradrenergic r
Pain thresholds were measured before (pre-session) and after (post-session) the experimental session. The mean and standard deviation are given in degrees Celsius. The average ratings with standard er